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Alnylam Pharmaceuticals sucht Manager – Market Access – Europe & Canada

Alnylam Pharmaceuticals 5<y Senior Level  Zug, Zug, Schweiz 9 Feb 2017

Job Description

Alnylam was founded in 2002 on a revolutionary vision and bold mission which remain firmly in place today. We are leading the translation of RNAi as a new class of medicines with a core focus on RNAi therapeutics toward genetically defined targets for the treatment of serious, life-threatening diseases with limited treatment options for patients and their caregivers. In January 2015, we announced our “Alnylam 2020” guidance that reflects our expected transition from a late-stage clinical development company to a multi-product commercial-stage company with a sustainable development pipeline. Alnylam is proud to have been recognized as one of The Boston Globe’s Top Places to Work in 2015 and 2016.Alnylam is seeking to hire four highly experienced, driven and innovative

leaders who will build the Market Access capability in Europe and Canada (EU/Can).

The positions can be based at Alnylam’s European headquarters in Switzerland or in Alnylam’s country offices.

Position OverviewThe Market Access capability is of critical importance to Alnylam, and the company aims to be an innovator in this area. Our aim is to achieve and maintain appropriate pricing and market access through propositions that deliver value to patients, health care systems, society and the company. Our goal is for Market Access to be a capability that both develops and executes strategy, and one that is fully integrated across all functions within the organization. Additionally, the Market Access team is expected to locally execute pricing and access strategies, in coordination with the General Managers of each market. As such, the Market Access team has both internally and externally facing responsibilities.Alnylam Defines Market Access Broadly And Includes The Following Core Disciplines, Each Of Which The Company Believes Are Critical Tools To Support The Development And Execution Of Market Access Strategies

  • Pricing analytics and operations: Competitive intelligence, price negotiation strategies, global price referencing and reporting, price forecasting and modeling, internal price governance, price tracking and benchmarking
  • Health economics and outcomes research: Health economic modeling, global health technology assessment procedures and guidelines, evidentiary threshold assessments of pipeline assets, evidence synthesis and dissemination, clinical trial design and data analysis
  • Health policy shaping: Global and country-level policy analysis, public affairs, government relations, trade and industry association strategies, patient advocacy, development and execution of corporate health policy activities
  • Local market access execution: Local pricing and reimbursement procedures, stakeholder mapping, direct customer/payer engagement with local authorities, local price negotiations, patient and health care professional (HCP) support services

The roles will help define the Alnylam approach to Market Access in the region and help build an organization that can execute cross-functionally in time for multiple product launches from 2018 onwards. The roles will report to the Vice President, head of Market Access, EU/Can and maintain significant relationships with affiliate country and product General Managers with whom pricing and access performance objectives will be shared. Titles and levels for each role will be dependent on level of demonstrated past experience.As a group, the EU/Can Market Access team is expected to work across these domain areas and other company expertise areas (e.g. Medical Affairs) and the US Access team, in order to meet its objectives of achieving and maintaining appropriate pricing and access. Consequently, each team member is expected to bring a high-level of experience in at least one of these domains, and must also show a strong commitment and potential to develop and work across all domains. All team members are also expected to have both regional and country-level objectives, such that the execution of in-market access strategies and the delivery of plans in each of the access domains are achieved by one high-performing team. This is a rare and unique opportunity to have a broad market access role that shapes regional strategy and also involves ‘hands-on’ direct payer interactions in multiple countries. The working environment will be fast-paced, results-oriented, practical, and dynamic, all in keeping with the nature of an emerging pre-commercial biotechnology company that has global ambitions.Responsibilities


  • Local market access execution:
  • Ensure that global, regional and country pricing and access strategies are of high quality and are fit for purpose for the individual country
  • Ensure development of deep country-level understanding of payer needs, decision-making approaches, strategies, and country reimbursement stakeholders and influence map
  • Based on insights, develop pricing & access strategy incorporating additional evidence needs, value proposition beyond the drug, managed entry schemes and other agreements to ensure mutual value, and pricing strategy.
  • Coach others as needed for execution of country strategies, and directly engage external authorities as needed.
  • In collaboration with country General Managers, lead and own the local pricing & reimbursement processes in individual markets
  • Health Policy shaping
  • Lead EU-level policy efforts, including trade association engagement (e.g. EUCOPE, Europabio)
  • Define a policy agenda for the organization, making clear links between policy, business, and patient access outcomes
  • Ensure close collaboration with Communications / PR teams as appropriate
  • Professionally represent the company externally
  • Ensure the company has developed appropriate broad stakeholder relationships to support access engagement and education – including appropriate consultation of patients regarding their needs and the impact of the disease in their local context
  • Ensure robust, timely local advocacy efforts involving all customer-facing Alnylam teams
  • Establish and maintain personal relationships with select payers, advisors, key opinion leaders and other stakeholders
  • Health economics and outcomes research
  • Ensure that global evidence plans meet local country needs, or supplement with tailored strategies for each market
  • Lead development of health economic and outcomes analyses (CEA, BIA, burden of disease, etc.) required for access, working in collaboration with internal cross-functional teams in medical affairs and R&D
  • Proactively identify evidence requirements for successful access in EU/Can and support creation of program-specific evidence generation plans
  • Ensure that patient-reported evidence is gathered and communicated as needed
  • Ensure evidence synthesis activities (systematic reviews, indirect comparisons, dossier development, etc.) are performed to optimally meet EU/Can payer needs and support successful product positioning
  • In collaboration with country General Managers, directly engage payers and health authorities (e.g. NICE, CADTH, TLV, etc.) as needed to support positive technology assessment outcomes
  • Develop compliant communication tools to be used in discussions with payers
  • Pricing analytics and operations
  • In alignment with global strategy, develop and implement EU/Can country pricing and reimbursement strategy per product
  • Work with internal commercial teams to support development of accurate and robust product forecasts
  • Develop and maintain and internal pricing infrastructure that optimally tracks product prices in-market, gathers competitive intelligence, and efficiently produces decision-support analyses (business cases, trade-off analyses)
  • Support development of innovative pricing and reimbursement approaches, based on value delivered.
  • Ensure co-ordinated negotiation strategy per country, with clearly defined negotiation approach. Train and coach others through negotiations, and directly attend negotiations as needed
  • Market access overall
  • Collaborate with product teams and country teams to ensure that investments in services and treatment pathway interventions are valued by payers
  • Leverage science and product data effectively and convincing
  • Support the execution of broader market access goals, including pricing targets, revenue targets, access timelines, and overall launch success

Experience Requirements

  • Strong experience in pricing and reimbursement in Europe at both country and regional level.
  • Demonstrated experience supporting the regional launch of innovative therapies; rare disease experience a plus
  • Experience in policy engagement including industry association participation
  • Hands-on experience with country pricing negotiations; Demonstrated knowledge of pricing trends, tactics, and EU/Can payer dynamics
  • Hand-one experience with major HTA/payer authorities (e.g. NICE, TLV, Infarmed, CADTH); Demonstrated experience achieving positive HTA outcomes
  • Experience and proven success working with cross-functional teams across geographies
  • Demonstrated success in managing multiple activities (both “self” and through delegation) and working in a fast-paced environment
  • Clear knowledge (expert level) in one of the defined market access domains, coupled with experience in other domains. Ability to see the ‘bigger picture’ in market access and work across domains is a must
  • Examples of relevant experience may include: pricing/contracting strategy lead for a regional organization; lead for P&R/access activities in a specific EU market; HEOR lead for a product/brand; policy or public affairs lead for a region or specific EU market; banking, business planning or financial analysis experience; corporate strategy or top-tier consulting

Skill Requirements

  • Strong leadership and influencing skills
  • Ability to drive progress through both personal engagement and by influencing others across the organization
  • Ability to effectively manage very senior level relationships, internally and externally
  • Exceptional written and oral communication, and organizational skills
  • Exceptionally strong collaboration and alignment building skills with key stakeholders
  • Strong collaborative negotiation skills
  • Clear understanding of how to best put patients’ needs first while also achieving commercial and business objectives
  • Demonstrated awareness of the highly-regulated and sensitive nature of pharmaceutical pricing
  • Strong strategic skills.
  • Ability to obtain deep external stakeholder insights and combine these with clinical data to develop robust access strategies
  • Strong learning agility and ability to engage in-depth across multiple disease areas
  • Creative and innovative thinker
  • Strong execution management skills
  • Detail oriented with while maintaining a balance with the big picture perspective
  • Ability to effectively drive execution by dotted line staff, cross-functional team members, and external vendors
  • Ability and willingness to be both a strategic leader and be “hands on”
  • Ability to work across market access disciplines to achieve company objectives
  • Clear ability to work across cultures, languages, and geographies, traveling frequently as the business requires. Multiple languages preferred and would help ensure success in the position.

Education (Minimum) Requirements

  • Bachelor’s degree.
  • MBA or PhD in science and/or economics preferred


  • Clear alignment with Alnylam Core Values:
  • Commitment to People
  • Innovation and Discovery
  • Sense of Urgency
  • Open Culture
  • Passion for Excellence
  • Commercial/Market Understanding: Deep understanding of commercialization model in severe / rare diseases, including diagnosis and treatment dynamics
  • Strategic Thinking: Understands healthcare industry and local market trends and develops strong strategies for driving market value of assets accordingly
  • Business and Commercial Acumen: Able to identify significant opportunities; understands how to interpret performance data to prioritize resources and develop plans.
  • Financial planning: Understands differential resource deployment, monitors and understands the ROI of different initiatives/ programs to make informed decisions
  • Influence and Leadership: Influences without formal authority, understands role/ position in the wider context; able to build strong teams and maintains strong relationships
  • Alignment: Effective listening and communication skills; gathers input from key stakeholders; communicates scientific and commercial strategies clearly and timely
  • Work style: Works collaboratively across functions and regions; seeks to advance higher goals; highly regarded across stakeholders both at senior and junior levels; inspires trust at all levels; committed team player

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.


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